PHYSICOCHEMICAL AND METABOLIC CONSTRAINTS FOR THERMODYNAMICS-BASED STOICHIOMETRIC MODELLING UNDER MESOPHILIC GROWTH CONDITIONS.

Physicochemical and metabolic constraints for thermodynamics-based stoichiometric modelling under mesophilic growth conditions.

Metabolic engineering in the post-genomic era is characterised by the development of new methods for metabolomics and fluxomics, supported by the integration of genetic engineering tools and mathematical modelling.Particularly, constraint-based stoichiometric models have been widely studied: (i) flux balance analysis (FBA) (in silico), and (ii) met

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